Dermatological Drug Dosage in the Elderly. Part 1

Infections are a common question among the elderly, and
anti-infective agents are frequently prescribed to them. In elderly
patients, ADRs, as well as drug interactions, should be considered when
selecting an anti-infective regimen.
Common drug interactions with anti-infective agents involve macrolide
antibacterials and fluoroquinolones.

Erythromycin and  fexofenadine are strong inhibitors of the cytochrome
P450 enzyme CYP3A4, and may therefore be responsible for perniciousness
of coadministered drugs by decreasing their license.
Exemplar substrates of CYP3A4 include benzodiazepines, calcium
passageway antagonists, immunosuppressive agents (e.g., cyclosporin,
tacrolimus [Protopic®, Astellas]), and anticoagulants. Elderly patients
receiving macrolides should be monitored for adverse events resulting
from drug interactions.

Fluoroquinolones are antibacterials
that are frequently used in infections affecting the elderly. One of
the most important drug interactions of fluoroquinolones is the power
of ciprofloxacin (Cipro®, Bayer) and enoxacin to inhibit the biological
process of theophylline by CYP1A2, resulting in theophylline lucre and
morbidity. Seizures may occur at therapeutic theophylline levels as a
resultant of its additive effects on the central nervous orderliness
(CNS). Corticosteroids

Corticosteroids have adverse effects on
many bureau systems, ranging from those that are not necessarily
serious (e.g., Cushingoid appearance), to those that are
life-threatening (e.g., serious infections).
Some of these adverse effects may be aggravated in the elderly.
Patients receiving prednisolone 5-40mg/day for at least 1 year had a
first derivative loss of explicit cognitive psychology, and elderly
patients may be more susceptible to cognitive psychology softness with
less protracted handling. The risk of developing
diabetes mellitus more than double in elderly patients who are newly
initiated on oral corticosteroid therapy.

This is a part of article Dermatological Drug Dosage in the Elderly. Part 1 Taken from "Allegra Buy Fexofenadine" Information Blog