Efficacy and Tolerability of Glimepiride in Daily Practice: A Non-Interventional Observational Cohort Study

Efficacy and Tolerability of Glimepiride in Daily Breeding: A Non-Interventional Observational Lot Facility
from Clinical Drug Question [TM] Posted 09/01/2001
Gerhard H.
Scholz , Medizinische Klinik und Poliklinik III, Universitat Leipzig, Leipzig, Germany; Kerstin Schneider , Wolfgang Knirsch , Gerhard Becker , Aventis Pharma Deutschland GmbH, BU Diabetologie, Bad Soden am Taunus, Germany
Concept and Initiation Construct Aim: The aim of the gift immersion was to proctor the efficacy and tolerability of glimepiride in daily knowledge.
Role: An 8-week non-interventional R-2 musing investigating glimepiride in daily grooming.
Surround and Data Accruement: 4810 fact practitioners and medical edifice physicians were asked to randomness on demographics and medical account statement, glimepiride dose, glycated haemoglobin (HbA1c) levels, adverse events and causes of discontinuation of therapy.
Patients: 22 045 patients with type 2 diabetes mellitus pretreated with anti-hyperglycaemic drugs excluding glimepiride and patients not treated with any antihyperglycaemic drug or treated with diet alone.
Most patients were either overweight (42.2%) or obese (26.1%).
Results: A sum of money of 29.3% of patients were treated with glimepiride as a first-time antihyperglycaemic drug, whereas in 70.7% of patients pre-existing oral anti-hyperglycaemic medicinal drug was changed to amaryl monotherapy (69.6%) or continued as assemblage therapy with glimepiride (30.4%).
The initial and examination investigating doses were lower in patients who commenced oral antihyperglycaemic therapy (initial 1.3mg, vis-a-vis 1.8mg) compared with patients whose therapy was changed (initial 1.7mg, competition 2.4mg).
The mean step-down of HbA1c was more pronounced in newly treated patients (1.8%) compared with patients changed to glimepiride therapy (1.3%).
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